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Secondary endpoints: influence of antioxidant supplementation on tumor, quality of life and compliance with radiotherapy Interaction of antioxidant supplementation with tumor Twelve studies examined the interaction of antioxidant supplementation with tumor (vitamins: n = 7, curcumin: n = 3, flavonoids: n = 2)

These proinflammatory molecules also induce the above lesions through the nuclear factor-B (NF-B), Janus kinase/signal transducers and activators of transcription (JAK/STAT), and TGF-/Smad signaling pathways[99-101]