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By promoting GDP-loading of RagC, FLCN facilitates interaction of TFEB/TFE3 with Rags, thus inducing cytosolic retention (Cui et al, 2023

These enzymes function by nucleophilic attack on carbon 1 of fosfomycin, which opens the epoxide ring and renders the drug ineffective

Leaky gut syndrome otherwise called intestinal permeability occurs when an unhealthy gut environment breaks down the mucosa lining the small intestine