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A meta-analysis and systematic review of the literature

By secreting IFN-, CD8+ T lymphocytes within the TIME trigger ferroptosis and enhance lipid peroxidation, which promotes anti-tumor responses

[DOI] [PMC free article] [PubMed] [Google Scholar] Wang S, Zhu W, Wang X, Li J, Zhang K, Zhang L, et al

doi: 10.1016/j.cmet.2006.03.005

In order to bind both targets and still maintain the overall structure of a typical antibody, four unique heavy and light chains were paired by engineering amino acid substitutions known as charge pairs (10)