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The lack of extensive human clinical trials means theres no officially established optimal dose

People who regularly drink heavily can also have changes in metabolism some develop tolerance, but heavy chronic drinking can impair the livers efficiency over time

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Because of the side effects in people, however, it was relegated for use in veterinary medicine

199 Even with various antioxidant systems in place, the production of ROS could surpass the ability of the defense network, leading to oxidative stress