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Neuronal nicotinic acetylcholine receptors (nAChRs), the molecular targets of nicotine, and nicotinic cholinergic mechanisms contribute to dysfunctions such as schizophrenia, Parkinsons disease, autism, Alzheimers disease (AD), and addiction (Dani and Bertrand, 2007)

Individual responses vary widely based on pre-existing conditions, dose, diet, and lifestyle factors

Maintaining adequate vitamin B12 serum levels may help improve mental health by decreasing the risk of depression and anxiety

8,9 Patients typically complain of pain that starts with the first step on arising in the morning or after prolonged sitting

This could help in selecting patients who could benefit from a specific, adapted therapy