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Since SIRT1 has antioxidant, anti-inflammatory, and genomic stability effects, and it is highly expressed in microglia and neurons in the human brain (Cho et al

The most prevalent adverse events were nausea (15.4%-19.1%), diarrhea (10.1%-12.6%), vomiting (6.6%-7.5%), and constipation (5.8%-6.5%)

Severe headaches that are worse in the morning, associated with nausea and vomiting, and worse with coughing and sneezing is a rare side effect of Isotretinoin and means treatment must be stopped immediately, and a neurological review is required

NICE has not yet issued guidance on either agent, as appraisal processes are typically initiated only after regulatory approval, although scoping can occur earlier

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