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Considering the successful application of nanoparticles in drug loading, various insulin delivery systems have been developed, including (poly (lactic-co-glycolic acid), PLGA), hydroxyapatite (HA), gelatin, chitosan, alginate, and (-glutamic acid)/-tricalcium phosphate, -PGA/-TCP)

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On the basis of the line of defense, antioxidants can be categorized as first-line defense antioxidants, second-line defense antioxidants, third-line defense antioxidants and fourth-line defense antioxidants [137]

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