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In posing health risks on the bodys cardiovascular system, smoking: Causes immediate and long-term increases in blood pressure Causes immediate and long-term increases in heart rate Reduces cardiac output and coronary blood flow Reduces the amount of oxygen that reaches the bodys tissues Changes the properties of blood vessels and blood cells, allowing cholesterol and other fatty substances to build up Contributes to an increased risk for blood clot formation Damages blood vessels Doubles the risk for ischemic stroke (reduced blood flow to the brain) Smoking has also been linked to depression and psychological distress