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In this manner, prenatal exposure to environmental toxicants or alterations in prenatal nutrients could predispose the mitochondria to be sensitive to post-natal physiological stressors [91], such as an infection or inflammatory event or other toxicant exposures

This will reduce the protection provided by the HPA axis, attenuating immune and inflammatory changes, and leaving ME/CFS patients more vulnerable to minor stressors (429)

Allogeneic mesenchymal stem cells ameliorate aging frailty: a phase II randomized, double-blind, placebo-controlled clinical trial

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