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Intravenous N-acetylcysteine is associated with fewer of the adverse effects seen with the oral preparation, such as nausea, vomiting, abdominal pain, diarrhea and rash, but it carries a higher risk of anaphylactoid reactions.9 When patients present relatively late after ingestion, oral N-acetylcysteine protocols provide a higher dose given over a longer period, which may be an advantage.2 , 10 However, the gastrointestinal adverse effects associated with oral therapy are a substantial disadvantage, notably if this results in a longer time for drug absorption and hence a longer time to reach therapeutic effect.2 Since the introduction and adoption of routine use of N-acetylcysteine therapy, the mortality rate in acetaminophen overdose has declined from 3% to 0.7%.11 Prevention of overdose and medication errors in children This report highlights the issue of accurate dosing in pediatrics

Konopleva M, Ruvolo P, Contractor R, Kurinna S, Xie Z, Milella M, Andreeff M

Furthermore, patient-derived aging-on-a-chip systems further dissect single-cell mechanisms of reproductive decline and, within the same circuit, test reprogramming factors or anti-aging agents, offering a unified strategy to delay or reverse female reproductive aging 186

Scheibenbogen C, Freitag H, Blanco J, Capelli E, Lacerda E, Authier J, et al

Tang J, Salama R, Gadgeel SM, Sarkar FH, Ahmad A