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Essentially, the toxins found in cigarette smoke cause the increased production of free radicals that attach themselves to lung cells and cause their damage or death, according to a study published in 2008 in the American Journal of Respiratory and Critical Care Medicine

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Xi C, Liu N, Liang F, Zhao X, Long J, Yuan F, et al

This has implications in blast induced TBI in a battle field setting

In this model trace NO would preferably react with nucleophiles such as lipids, DNA and metal centered proteins but also with oxygen species forming oxidizing and nitrating species including ONOO and NO 2