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The 13-amino-acid N-terminal extension (sequence MFPAMPLLSLFVN) shifts the three-dimensional conformation of the binding interface, while the Arg 3 Glu 3 substitution disrupts a key contact residue with IGFBPs

Conclusion This study confirmed that trophoblast ferroptosis occurs in the pathological state of PE and that trophoblast are specifically sensitive to ferroptosis

doi: 10.1038/s41467-020-20001-w [DOI] [PMC free article] [PubMed] [Google Scholar] 40

Typically, its recommended to apply a thin layer of cream to clean, dry skin once or twice daily