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In mammalian cells, it was shown that the HIF-prolyl hydroxylases were represented by a series of isoforms bearing a conserved 2-histidine-1-carboxylate-iron coordination motif at the catalytic site

Results revealed a higher mtDNA copy number in Epitalon-treated oocytes compared to untreated aged counterparts, further supporting the idea that Epitalon maintains mitochondrial integrity during oocyte aging

People who are pregnant or breastfeeding, those with kidney disease, seizure disorders, or thyroid conditions, and anyone on medications that could interact should avoid it unless a physician specifically approves it

Huang PL

10.1186/s13075-020-2119-032087742 130 Liang L, Hou X, Bainey KR, et al