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The X-linked gene methyl CpG binding protein 2 (MeCP2) is a transcription factor that represses gene function and influences downstream molecules implicated in ASD, such as brain-derived neurotrophic factor (BDNF) and CDKL5 [164]

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CD300b and its adapter, DAP12, activated splenic tyrosine kinase (Syk) and PI3K upon binding to LPS and TLR4, promoting the dissociation of MyD88-TIRAP, which further inhibited the activation of the MEK1/2-ERK1/2 and NF-B pathways via AKT, thereby inhibiting the production of the anti-inflammatory factor IL-10 and driving the cytokine response and aggravating septic shock