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Statistics and reproducibility All experiments were repeated three times

Observed adverse effects are mild: nasal irritation from intranasal delivery, transient headache, and in semax specifically, a modest increase in blood glucose in diabetic patients in one study

early onset of osteoarthritis

Therefore, PPOs featuring a hydrophobic amino acid at the 2 nd activity controller position do most likely target substrates with a less polar aliphatic chain, whereas substrates with a negatively charged group at their aliphatic chain are more readily accepted by PPOs carrying an arginine at this position

Fan J, Han Y, Sun H, Sun S, Wang Y, Guo R, et al