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Massey V, Williams C (1965) On the reaction mechanism of yeast glutathione reductase

We observed upregulation of DNMTs , but literature also reported increased protein levels and catalytic activity by interaction of DMSO with their enzymes substrates (DNA and AdoMet) 19,29,30

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Front Cell Dev Biol 8:615461

The extracellular signalingregulated kinase (ERK) pathway is the most prominent and clinically utilized target, while the Jun N-terminal kinase (JNK) pathway and p38 pathway play critical modulatory roles in cancer cells