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In pyrimidine biosynthesis, one glutamine molecule is consumed by a carbamoyl phosphate synthetase enzyme (CPS1 or CPS2, which are localized in the mitochondria and cytosol, respectively)

At millimolar concentrations, PAG also inhibits other enzymes such as aspartate aminotransferase and alanine aminotransferase [42, 43]

It is interesting to report that a derivative from HD which was modified enzymatically through glycosylation and de-rhamnosylation could alleviate ALD through preventing excessive lipid formation, protecting the antioxidant system and suppressing induction of inflammation in hepatocytes (Park et al., 2013)

2014, article ID 768026, 7 pages

Future studies should validate our findings in genetic models to determine whether the observed gut-brain interactions are generalizable across ASD subtypes