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10.19540/j.cnki.cjcmm.20210621.401 17 FanY.QianH.ZhangM.TaoC.LiZ.YanW.et al (2023)

Glutathione is the liver's primary tool for "Phase II detoxification." In this phase, the liver attaches a glutathione molecule to a toxin, making it water-soluble so it can be excreted through bile or urine

doi: 10.3389/fphar.2025.1632588 Received 21 May 2025 Accepted 28 July 2025 Published 29 August 2025 Volume 16 - 2025 Edited by Yurong Lai, Gilead, United States Reviewed by Daniel Crona, University of North Carolina at Chapel Hill, United States John Prybylski, Pfizer, United States Updates Copyright 2025 Cao, Qian, Wang, Zheng, Huang, Wei, Jiang, Yu, Jiang, Yu, Mao and Zhai

Beyond this direct chemical defense, NO also functions as a critical signaling molecule, modulating protein function through regulatory S-nitrosylation to actively suppress the ferroptotic cascade

Minor irritation or early-stage ulcers may respond more quickly, while chronic conditions, severe ulcers, or extensive tissue injury require longer periods for repair