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The assessment of results was made at 24 and 96 hours after peptide administration and included changes in the kidneys on a scale from 0 to 3, where: 0 - healthy kidney, 1 - mild hydronephrosis, 2 - moderate hydronephrosis, visible dilation of the renal pelvis, few changes on the kidney surface, 3 - severe hydronephrosis, dilation of the renal pelvis, thinning of the renal parenchyma, and a significant number of changes on the kidney surface

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On the contrary, NRF2 activators targeting KEAP1 thiols are recognized for their preventive potential for oxidative stress-related pathology such as Parkinsons disease, but have not proven effective for chronic patients largely due to their electrophilic high off-target nature [93]