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Riluzoleblunts the effects of glutamate accumulation and can extend survival by a few months Edaravonea free radical scavenger that can reduce oxidative stress Other treatments may help relieve symptoms and improve quality of life: Non-invasive positive pressure ventilation Medications to relieve painful muscle cramps Medications to reduce excessive salivation Physical, occupational, and speech therapy Mobility aids What are Emerging Therapies for Amyotrophic Lateral Sclerosis

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Hellman L, Bradlow HL, Zumoff B, Fukushima DK, Gallagher TF

By competitively binding FOXO4, it prevents FOXO4 from sequestering p53, thereby restoring the cells intrinsic apoptotic signaling capacity

doi: 10.1111/imm.12388 90 MichalekRDGerrietsVAJacobsSRMacintyreANMacIverNJMasonEFet al