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Interestingly, it has recently been suggested that Tfam heterozygous knockout mice, which undergo mild mtDNA depletion 49, also exhibit increased oxidative mtDNA damage susceptibility although the underlying mechanism is unclear 50

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This indirect effect can significantly impact pigmentation over time

These studies have shown that quercetin exerts anti-RA effects mainly through anti-inflammation, immune regulation and inhibition of osteoclasts formation

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