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[DOI] [PMC free article] [PubMed] [Google Scholar] 154.Wilkie D.A., Latimer C.A

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The persistence of SARS-CoV-2 or its viral components in the body could trigger a dysregulated immune response and proinflammatory cytokine release, which may cause chronic low-grade inflammation and MODS

Excretion occurs primarily through the kidneys and bile, with efflux transporters such as P-gp playing a key regulatory role

The oestrogenhistamine feedback loop is particularly significant for women: This self-amplifying cycle explains why histamine intolerance symptoms are consistently worse in the days before menstruation (when oestrogen is relatively elevated and progesterone is falling), around ovulation, and during perimenopause when hormonal fluctuations intensify