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On this basis, we will reflect on why abundant preclinical mechanistic insights have failed to translate into significant clinical benefits, and take this as an opportunity to examine the practical challenges and future opportunities faced by current innovative therapeutic strategies targeting this axis

Under section 1886(d)(3)(E) of the Act, beginning with FY 2005, we delineate hospital labor market areas based on the Core Based Statistical Areas (CBSAs) established by OMB

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