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Aborted LR3 clinical studies in oncology (late 1990s) highlighted the complexity of IGF-1R targeting: mitogenic potential on mammary and prostate tumor lines, requiring abandonment of development in favor of IGF-1R antagonists (monoclonal antibodies such as figitumumab, ganitumab, dalotuzumab) which also encountered phase III failures but enriched understanding of the IGF axis role in carcinogenesis

HDAC inhibition by SNDX-275 (entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML

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This consideration is based on the fact that independent regulation of gliT may have enabled acquisition of functionality beyond a role in gliotoxin biosynthesis or auto-protection

Methane is also a net loss of feed energy to the animal [21]