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In the context of type II diabetes, metformin-induced activation of AMPK leads to increased trafficking of GLUT transporters to increase glucose uptake and glycolysis, thereby, lowering blood glucose (Pernicova and Korbonits, 2014)

Free Radical Biol Med 160:552565 Zhang S, Lv Y, Luo X, Weng X, Qi J, Bai X et al (2023) Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder

Synergistic activation of p53 family of proteins by the combination of Nutlin 3a and SAHA in acute myelogenous leukemia, poster presentation

When pathogenic bacteria and viruses attack, they hijack TJ proteins to enter and infect cells and promote inflammatory factor production (68)

Likewise, polyphenols or omega-3 fatty acid combinations with chemotherapy are studied for pharmacodynamic synergy by means of endpoints such as tumour volume reduction, progression-free survival and amelioration of chemotherapy-induced toxicity along with quality-of-life enhancement, keeping a close watch for antagonistic interactions or organ-specific adverse effects (234)