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178 Compared with traditional single-target agents, SIRT1 activators simultaneously modulate several critical pathways, including metabolism, immune responses, and oxidative balance, offering a network reprogramming therapeutic advantage, particularly in the early stages of the disease when multiple processes are synergistically dysregulated

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2016, 17.: 10.3390/ijms17091584 118.0 118.1 Bhutto IA, McLeod DS, Hasegawa T, Kim SY, Merges C, Tong P, Lutty GA: Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

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