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A key future direction involves defining optimal drug ratios and identifying predictive biomarkers to guide patient selection for such metabolically targeted combination therapies

HES (for 10 days) to CIPN rats significantly reduced PTX-induced increases in MDA, NF-B, IL-1, TNF-, COX-2, nNOS, JAK2, STAT3, and GFAP levels with neuropathic pain and alleviated endoplasmic reticulum stress (ERS) [133]

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He P, Hou Z, Song C, Wang C, Li B, Imam M (2017) Resveratrol ameliorates experimental alcoholic liver disease by modulating oxidative stress