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A decrease in the CD18 expression led to a decrease in the inflammatory process, indicating that zerumbone has the potential to be developed into an immunosuppressant ( + and CD4 + in splenocytes (Jantan et al., 2019)

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Clinical studies support these findings: in diabetics aged 35-65 years, kefir supplementation reduced fasting blood glucose and HbA1c levels (Ostadrahimi et al., 2015), and in newly diagnosed type-2 diabetic males, kefir combined with metformin improved multiple biochemical markers (El-Bashiti et al., 2019)