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Consequently, UPR is activated to resolve this protein-folding defect and thus to restore ER homeostasis

10.1186/s40360-022-00622-1 241 YangR.ChangQ.MengX.GaoN.WangW

Across most animal and human studies, two primary routes dominate [1]: Subcutaneous injection : Used in numerous rodent studies (typically 0.110 g/mouse/day) and in human trials (commonly 0.51 mg/day), especially in circadian and immune studies

10.1126/science.1260144 Science 11 BelloneM.BreviA.HuberS

Treatment-nave patients saw a median DoR of 13.4 months with a 78% ORR, while patients previously treated with platinum-based chemotherapy had an ORR of 63% and DoR of 38.8 months