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Arg1, arginase 1

About 50% of patients with melanoma have BRAF mutations and 1520% of NRAS mutations leading to the constitutive activation of the MAPK signaling pathway [2] and Chattopadhyay et al

In addition, the levels of ATF4 and GRP78 are shown in (Figures 7D, E)

Gpx4 is a crucial intracellular lipid peroxidation-detoxifying enzyme (Yant et al., 2003), and its inactivation not only participates in ferroptosis but also remains the main mechanism supporting this process (Krantz et al., 2005