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Interestingly, vitamin E could also prevent lipid peroxidation and inhibit ferroptosis [166, 167]

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Figure 1 1.2.1 Changes in Spinal Cord The increased spinal neuronal activity due to neuropathy can be linked to the enhanced activity of the dorsal horns ( 1.2.2 Initial Pathological Changes in the Dorsal Root Ganglion (Primary Triggers for Neuropathic Pain) Major changes in primary sensory neurons altered gene/protein expression

Both pathways are considered to be stress-responsive and play an important role in ROS defense and cell survival during oxidative stress [44]