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This combination is particularly concerning given that cannabis plus alcohol is one of the most frequently detected drug combinations found in car accidents

Resulting physiological effects include antimicrobial effects via FXR-induced antimicrobial peptide production (115)

Thus, this early research suggests that huperzine A is indeed capable of crossing the blood-brain barrier , meaning that it is reasonable to believe that taking it results in it actually getting to the brain (where it could have some of the cognitive effects described in the previous sections of this post)