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10.1016/S0300-9629(96)00166-1 Res

Furthermore, in some cell models, a small proportion of DTCs can resume normal growth and form cell populations even in the presence of drugs, indicating that in a few cases, DTCs can also mutate and cause drug resistance (12)

Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

They postulated that peroxides stimulate prostaglandin H (PGH) synthase, leading to the generation of oxygen radicals and increased formation of both thromboxane and lipid peroxides