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Laryngoscope 122(2):266270

Tissue fibrosis was quantified in females [Young ( n = 4), Old Con ( n = 5), and Old mAb ( n = 5)] and males [Young ( n = 8), Old Con ( n = 8), and Old mAb ( n = 8)], by counting blue stained interstitial collagen within three random fields using Image J and values were averaged

Patients are randomly assigned to either the treatment group or a control (placebo) group

No published time-course demonstrates diminishing effect, and mechanistic reviews note the absence of receptor desensitization that would predict tolerance

Someone in their late twenties addressing early prevention will see different results than someone in their fifties targeting deeper structural aging which is exactly why a personalized consultation matters more than generic before-and-after photos ever could