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The sensitivity analysis of breastfeeding pattern, in which the number of feeds and the breast milk volume per feed were varied, showed no major impact on the predicted concentration-time profile, the maximum concentration (C MAX ), or area under the concentration-time curve (AUC) in infants for both primaquine and carboxyprimaquine (see Supplementary Figs

Discussion It has been previously suggested that altered trafficking of APP in aging neurons and its accumulation in neurites with age ( In this study, we found that A 42 stimulates the increase in APP level and its accumulation in neurites in human neuroblastoma SH-SY5Y cells