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As SOD2 is induced by hypoxia and subsequent HIF-1 activation, it is highly upregulated after wounding 52,53

Renal function: Dehydration secondary to gastrointestinal side effects can impair renal function, particularly in those with pre-existing kidney disease

Reported side effects are infrequent and mild: Mild headache or dizziness following administration

It will be interesting to determine whether the NPCs of the adult brain also use fluctuating gene expression and how this relates to their decision to generate neurons or astrocytes

By western blot analysis, we still found a large amount of p--syn in the hippocampal tissues of reoxygenated mice, suggesting that -syn pathology induced by chronic hypoxia was also irreversible for an extended period of time (Fig