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Description

Further, activated T cells recovered on day seven following allogeneic transplantation, during an early phase of activation, demonstrate a marked increase in FAO (122)

EEG Neurosci

doi: 10.1161/01.atv.13.4.590

Bioinform 26 (2), bbaf109

Mechanistically, this combination is also expected to reduce intracellular methionine availability by increasing anabolic demand (via GCN2 inhibition) while imposing oxidative and metabolic stress (via GCLC inhibition), creating a state of methionine limitation without the normal GCN2-mediated adaptive response