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Hayes JD, Dinkova-Kostova AT, Tew KD

Retinal oxidative stress induced by high intraocular pressure

In addition, MAPK, ribosomal S6 kinase (RSK), glycogen synthase kinase-3 (GSK-3) and p38 can all phosphorylate MITF and simultaneously modulate its transcriptional activity in response to specific environmental cues (39-43)

Klotho cleavage occurs at a site directly above the plasma membrane (-cut) or between the KL1 and KL2 domain (-cut), resulting in soluble full-length klotho or KL1 and KL2 fragments (97) ( Figure 6 )

Neurostimulation interventions are currently in development, with a few studies showing mild improvement in withdrawal symptoms