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Of the 2,570 MOUNJARO-treated patients who developed anti-tirzepatide antibodies during the treatment periods in these seven trials, 2% and 2% developed neutralizing antibodies against tirzepatide activity on the GIP or GLP-1 receptors, respectively, and 0.9% and 0.4% developed neutralizing antibodies against native GIP or GLP-1, respectively

Pfmdr1 Copy Number For all genotyping assays, DNA was extracted from FTA filter paper blots or whole blood (for ex vivo specimens) according to manufacturer instructions (QIAamp DNA Blood Mini Kit, QIAGEN, Inc, Alameda, California, USA)

Nerve Regeneration Peripheral nerve injury studies showed: Improved functional recovery Enhanced axonal regeneration Reference: Gwyer et al., 2019 5

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doi:10.1016/j.cell.2014.01.007 194