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Insulin-like growth factor (IGF) binding protein-2, independently of IGF-1, induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes

Also known as GH Fragment 176-191, AOD 9604 incorporates a tyrosine residue at the N-terminus that researchers suggest may contribute to the peptides stability in laboratory settings

[DOI] [PubMed] [Google Scholar] 86

Novo Nordisk paused Phase 3 development due to cardiovascular safety signals identified in Phase 2 trials specifically, consistent increases in resting heart rate and blood pressure across all dose groups

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