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This action is consistent with its known mechanism as a tetracycline derivative that suppresses activated microglia, the resident immune cells of the central nervous system (Tikka et al., 2001)

M.GiampietroA.MalatestaG.GambiD

However, in Wilson disease, the process is impaired and excess copper is initially deposited in the liver where it damages liver cells

This interaction reduces NRF2 stability, resulting in the accumulation of ROS, which promotes apoptosis in cancer cells and enhances their sensitivity to DOX and etoposide [106]