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[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Slifer Z, Pridgen T, Madan J, Krishnan RB, Blikslager AT

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To assess the effect of NS8593, a non-specific inhibitor of TRPM7[33], in neuronal damage and pyroptosis in PILO-treated mice, 5 mg/kg NS8593 was applied intravenously 30 min before PILO administration

Similar content being viewed by others Table of contents Introduction Structural Components of the Gut Barrier & Intestinal Immunity Cellular Components & Their Associated Functions Tight Junctions as Modulators of Intestinal Integrity and Paracellular Translocation The Gut Barrier: An Immunological Hotspot Factors Influencing Intestinal Barrier Integrity Environmental Factors Genetic Predisposition to an Attenuated Gut Barrier Mechanisms of Bacterial Translocation During Enteric Infection The Gut Barriers Role in Autoimmune Disease Inflammatory Bowel Disease Coeliac Disease Type 1 Diabetes Systemic Lupus Erythematosus The Gut-Joint Communication Axis in Rheumatic Disease Development Improving Intestinal Barrier Integrity to Limit Inflammatory Disease Development Conclusion Introduction Humans have evolved a highly complex and efficient gastrointestinal (GI) tract that plays a pivotal role in nutrient and water absorption, defence against pathogenic microbes, and overall body homeostasis (Allaire et al