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While several of these strategies have been successful in overcoming BBB limitations, there is also a concern that these new elements could themselves be toxic (Ajdary et al

VCAM-1 and ICAM-1 expression, induced by serum deprivation-mediated endothelial activation, was counteracted by PLC treatment (Fig 5H and 5I).The reduction of CAM expression by PLC was likely responsible for the inhibition of leukocyte adhesion, that characterizes endothelial activation (Fig 5J and 5K)

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