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Key findings from receptor studies [2] : Long-term studies in -AR knockout mice showed no body weight reduction or lipolysis increases This verified the receptor pathways importance for sustained metabolic effects Acute experiments showed AOD9604 increased energy expenditure even in knockout mice Results suggest -AR expression enhances sensitivity but additional mechanisms exist beyond the direct receptor activation cAMP-PKA-HSL Pathway Activation The peptide triggers increases in intracellular cyclic AMP (cAMP) within adipocytes

doi: 10.1210/jcem.80.9.7673411 140 FrieboesRMAntonijevicIAHeldKMurckHPollmcherTUhrMet al

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