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The primary function of cGAS-STING signaling is to trigger the innate immune response by inducing IFN-I production and subsequent interferon-stimulated gene (ISG) expression (16, 17)

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Immunity 51:856870.e855 Manolescu AR, Augustin R, Moley K, Cheeseman C (2007) A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity

however, this represents early-phase evidence only, and the mechanistic effects observed in trials including increased energy expenditure and lipolysis via glucagon receptor agonism have not yet been fully characterised in long-term human studies

The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging