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Along with this, we detected evidence of endothelial dysfunction in DM and DM_CKD, as indicated by reduced peNOS/eNOS ratios [60, 64]

At functional gene level, we observed a net decrease in the microbial potential to metabolize amino acids, likely as a direct consequence of the lower amino acid availability at caecal level, as linked to the increased nitrogen retention

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Dysfunctional energetics at the cellular level is believed to be a common mechanism

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