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Conclusion Multidrug resistance to chemotherapy drugs is one of the main obstacles in human cancer chemotherapy and has prompted intense research into discovering novel and innovative mechanisms that can overcome this barrier

In vitro, KYNA protects cortical neurons from reactive glia- and QA-induced atrophy, enhancing neurite complexity and synapse formation, indicating that increasing KYNA or inhibiting glial KP activity can mitigate excitotoxic and inflammatory neuronal damage [86]

In vitro studies indicate that thyroid hormones have a direct impact on the early development of the placenta by stimulating angiogenesis and by promoting the invasion and differentiation of embryonic cells (133)