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These findings highlight the potential of targeting ferroptosis as a novel therapeutic strategy for NAFLD, offering new avenues for disease management

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For instance, hypermethylation of genes such as brain-derived neurotrophic factor ( BDNF ) and SOX10 in the prefrontal cortex and hippocampus leads to reduced gene expression, impairing learning, memory, and neurodevelopment (polu et al., 2016

149 The traditional Chinese medicine formula XZTZ acts via SIRT1 to downregulate NLRP3 and GSDMD, reduce pro-inflammatory cytokines, and promote macrophage polarization from M1 to M2, improving the hepatic immune microenvironment