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Four Phase IV clinical trials of the vaccine are ongoing (EUCTR2021-002327-38-NL, NCT05030974, NCT05037266, and NCT05075538) ( Alter et al

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However, other heavier isoforms such as VEGF189 and VEGF206 remain bound to the ECM, with matrix-bound VEGF165, VEGF189, and VEGF206 all able to promote EC proliferation (172, 173)

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