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While Phase I safety trials in healthy adults reported no serious adverse events, a Phase II trial evaluating the compound in HIV patients with visceral obesity was ended early following one patient death from myocardial infarction

PTGS2 regulates cellular sensitivity to ferroptosis by regulating phospholipid P, a critical membrane component

In addition, further studies need to elucidate the usage of CCR6 as a co-receptor of HIV in the CNS, which will help to define its role in the establishment of an HIV reservoir and HAND